Generation of three hiPSC clones from a frontotemporal dementia (FTD) patient with a heterozygous MAPT mutation p.K298_H299insQ (c.896_897insACA)

A previously reported microtubule-associated protein tau (MAPT) mutation, p.K298_H299insQ, involving a glutamine insertion between lysine 298 and histidine 299, was identified in patients with frontotemporal dementia. We established induced pluripotent stem cell (iPSC) lines from a patient carrying this mutation. Generated iPSCs displayed typical pluripotency characteristics, differentiation potential into three germ layers, and stable karyotypes.