E Méndez Martínez, C García Cebrián, A M González González, P Sanabria Carretero, F Munar Bauzá, G Alcaraz García-Tejedor, P González Pizarro, D Méndez Marín, F Cassinello, J Encarnación Martínez, K Sifontes Romero, M Almena Marjalizo, C L Errando Oyonarte, F J Escribà Alepuz, J García Fernández
The mtND4 Working Group of the Spanish Society of Anesthesiology and Resuscitation (SEDAR) has issued clinical practice recommendations. This article stems from reports of neurological injury and death following general anesthesia in adult and pediatric patients of maternal Venezuelan ancestry, in whom a possible mitochondrial susceptibility associated with the mtND4 m.11232 T > C variant of respiratory chain complex I has been identified. This document is for informational and guidance purposes only. The final clinical decision should be individualized for each patient, taking into account the urgency of the procedure, therapeutic alternatives, and the resources available at each center.