Low-speed centrifuged platelet-rich fibrin membranes in recession coverage - Comparative clinical study

Background In vitro studies demonstrated uniform distribution of platelets and enhanced growth factor release from platelet matrices obtained by low-speed centrifugation concept. Aim This prospective split-mouth clinical study aimed to evaluate and compare the clinical efficacy of coronally advanced flap (CAF) in combination with either advanced platelet-rich fibrin plus (A-PRF+) or advanced platelet-rich fibrin (A-PRF) membrane in recession coverage. Materials and Methods Thirty-one subjects diagnosed with multiple gingival recession defects were randomly treated with either CAF + A-PRF+ (group 1, 70 sites) or CAF + A-PRF membranes (group 2, 72 sites). At baseline, six and twelve months post-surgery, clinical characteristics like recession height (RH), gingival thickness and width of keratinized gingiva were documented. Mean root coverage percentage (MRC) and complete root coverage percentage were calculated at 6 and 12 months. Visual analogue scale for esthetics and root coverage esthetic scores were noted at the end of research. Results Statistically significant reduction in mean RH was observed in both the groups from baseline to twelve months (group 1: RH baseline 2.38 ± 1.25 mm, 12 months 0.41 ± 0.63 mm (p < 0.001), group 2: RH baseline 2.48 ± 0.67 mm, 12 months 0.74 ± 0.81 mm (p < 0.001). The MRC values at 12 months were 86.23 ± 19.41 % for the CAF + A-PRF+ group and 72.83 ± 26.87 % for the CAF + A-PRF group. Intergroup analysis revealed no significant differences in the measured variables at baseline and follow-up visits (p > 0.05). Conclusion The research results suggest that both CAF + A-PRF+ and CAF + A-PRF interventions resulted in similar clinical outcomes in the management of multiple maxillary gingival recession defects.