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◆ Parkinsonism & related disorders2026-09-01

The classificatory ambiguity of task-specific tremor.

Daniele Birreci, Luca Angelini, Simone Aloisio, Anna S Grandolfo, Martina De Riggi, Alberto J Espay, Matteo Bologna

原始摘要(英文原文)· Original abstract
Task-specific tremor is a clinically heterogeneous phenotype that remains difficult to accommodate within current tremor classification. Although defined by its occurrence during a specific motor task, the boundaries with position-specific and isometric tremors remain uncertain. Additional classificatory complexity arises when a task-specific tremor phenotype is accompanied by neurological signs that remain subtle, questionable, or uncertain, such as possible dystonic posturing, rest tremor, mild bradykinesia, or response to alleviating maneuvers, and do not clearly support classification as a combined tremor syndrome, but raise the question of whether additional descriptive categories are needed. However, as in other movement disorders, caution is warranted against using additive labels to formalize uncertainty (the "plus" suffix) without biological, prognostic, or therapeutic validation. Available data suggest that the same task-specific tremor phenotype may reflect different underlying pathophysiological processes, with variable overlap with essential tremor, dystonia, and Parkinson's disease. This article addresses three unresolved issues in task-specific tremor: the interpretation of subtle neurological signs without prematurely introducing a "task-specific tremor-plus" category; the blurred boundary between task-specific, position-specific, and isometric tremors; and the relationship between heterogeneous clinical phenotypes and the available pathophysiological evidence. Rather than introducing new descriptive labels, we propose that these phenotypes should be approached through precise phenomenological description, quantitative characterization, and longitudinal follow-up, with the aim of determining whether they represent stable clinical variants, evolving combined tremor syndromes, or different expressions within a broader tremor spectrum.
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The classificatory ambiguity of task-specific tremor. — 科研速览 Science Skim