Naomi R. Philosof, Aidan P. G. Walsh, Bangyan Xu, Anna M.D. Watson, Shulei Ren, Ludmilla Hann, Benedict Nathaniel, Anne Nguyen, Haikun Liu, Pu Shi, Viktoria Bongcaron, Hung Nguyen, Jonathan Noonan, Meltem Avci‐Adali, Karlheinz Peter, Mark Louis P. Vidallon, Xiaowei Wang
in treated mice, with liver enzymes and histological analysis supporting formulation's safety and favorable tolerability. These findings establish CD39 mRNA-NLps as a safe, effective strategy for a spatially confined mRNA-based approach to regulate local inflammation.