Sustainable Synthesis of Aryl Pyrano-bis-coumarin and Dibenzo[a,j] xanthene Derivatives Using Organocatalyst Triethanol Ammonium Salt (tris (2-hydroxyl) Ammonium 2-(1,1-dioxido-3-oxobenzo[d]isothiazol- 2(3H)-yl) acetate) Under Microwave Irradiation.

INTRODUCTION: Recently, there has been a noticeable growth in the application of organocatalysts for the green synthesis of various organic molecules. Organocatalysts are efficient and sustainable agents for promoting chemical reactions in solvent-free conditions. In this study, a new triethanolammonium-based organocatalyst, tris(2-hydroxyethyl)ammonium 2-(1,1-dioxido-3- oxobenzo[d]isothiazol-2(3H)-yl) acetate, was efficiently designed and synthesized through a simple and environmentally benign procedure. METHODS: This organosalt was subsequently employed as a novel green catalyst for the synthesis of a wide range of aryl bis-coumarin (3a-j) and dibenzo[a,j]xanthene (5a-j) derivatives under solventfree conditions and microwave irradiation. RESULTS: The structures of the synthesized ionic liquid catalyst and heterocyclic products were fully characterized by NMR and IR spectroscopy, and the obtained spectral data were consistent with previously reported values for the corresponding compounds. Furthermore, various reaction parameters, including solvent, temperature, reaction time, and synthetic method, were systematically optimized to achieve the best operational conditions. DISCUSSION: In this study, various conditions, including solvent, temperature, time, and method of synthesis, were evaluated to determine the optimal synthesis conditions. CONCLUSION: Overall, this work introduces an efficient, sustainable, and operationally straightforward catalytic system for the green synthesis of biologically important heterocyclic molecules.