Tumor metaboception: local PGE2 signals global decline.

Cancer cachexia has long been attributed to circulating factors. Cross et al. now show that, in liver kinase B1 (Lkb1)-mutant lung tumors, local prostaglandin E2 acts on vagal neurons to drive anorexia and wasting, accelerated by fat. Defining metaboception as neural sensing of local signals-a new therapeutic concept.