Two helices are better than one: TMD-pairs redefine multipass membrane protein biogenesis.
Shunsuke Matsumoto, Toshiya Endo
原始摘要（英文原文）· Original abstract
In this issue of Molecular Cell, Smalinskaitė et al.1 reveal that transmembrane domain pairs (TMD-pairs), the fundamental biosynthetic units of multipass membrane proteins, are inserted into the endoplasmic reticulum membrane by Oxa1-family insertases through largely Sec61-independent mechanisms.