Research progress of exosomes derived from platelet-rich plasma in angiogenesis of chronic diabetic wounds

With the ageing of the population, the incidence rate of diabetes is also increasing an-nually. Difficulties in healing chronic wounds are common complications of diabetes and are highly detrimental to people's quality of life. There are many reasons why wounds are diffi-cult to heal. Among these factors, one of the most important is the obstruction of angiogene-sis. As important players in wound healing, platelets not only promote tissue regeneration and repair but also participate in the regeneration of blood vessels, playing an important role in improving wound healing in chronic diabetes. Research has revealed that the use of exosomes derived from platelet-rich plasma can significantly improve chronic wound healing in patients with diabetes. Therefore, exosomes derived from platelet-rich plasma have emerged as new targets for the treatment of chronic diabetic wounds. However, the standardized isolation, characterization, mechanism of action, and application of exosomes derived from platelet-rich plasma in the study of angiogenesis in chronic diabetic wounds have not been systematically described. This article reviews the latest advancements in understanding the mechanism by which exosomes derived from platelet-rich plasma promote angiogenesis in chronic diabetic wounds. It also reviews the therapeutic effects of PRP-Exos (hydrogel) and other novel applications. Consequently, this study systematically examines the research status and gaps in the understanding of how exosomes derived from platelet-rich plasma promote angiogenesis in chronic diabetic wounds, aiming to provide a theoretical basis for the further development and application of these exosomes in clinical treatment.