Spontaneous rupture of the urinary bladder and hereditary haemorrhagic telangiectasia (Osler-Weber-Rendu syndrome): a case report.

Spontaneous rupture of urinary bladder (SRUB) is a rare condition with no standard of care and significant related morbidity and mortality. Several predisposing factors have been reported, including malignancy, cystitis, binge drinking, bladder outlet obstruction, and connective tissue disorders. We describe the successful minimally invasive surgical management of a SRUB in a 60-years-old woman with known Osler-Weber-Rendu disease. After exclusion of all other recognized causes of spontaneous rupture of urinary bladder, perforation was considered most likely related to chronic inflammatory involvement of the urinary bladder, possibly associated to hereditary haemorrhagic telangiectasia. Although urinary bladder involvement in Osler-Weber-Rendu disease has been documented, typically presenting as hematuria secondary to telangiectatic lesions, to our knowledge this is the first reported case of a spontaneous rupture of urinary bladder associated with hereditary hemorrhagic telangiectasia.