Takuro Imaoka, Yudai Tamura, Nao Muraoka, Masaaki Shoji, Hirofumi Tomita, Yoshitaka Iso, Shiro Nakamori, Issei Komuro, Kazuko Tajiri, Yuichi Tamura
The score preserved discriminatory performance in Japanese cohort, but low scores did not exclude risk.
BACKGROUND: The International ICI-myocarditis Registry Risk Score predicts major adverse cardiotoxic events (MACE), but Japanese validation is limited.
METHODS AND RESULTS: In a retrospective multicenter Japanese registry (23 hospitals), 88 patients were analyzed. MACE occurred in 25 (28.4%) and increased stepwise with higher scores (0: 10%, 1: 13%, 2: 32%, 3: 50%, 4: 67%, 5: 100%; P = 0.001). Discrimination was preserved (AUC 0.76, 95% CI 0.65-0.88); a cutoff ≥2 yielded 80.0% sensitivity and 60.3% specificity.
CONCLUSIONS: The score preserved discriminatory performance in Japanese cohort, but low scores did not exclude risk.