Multiomics insights into bisphenol A induced metabolic remodeling in goat milk and selective removal by UiO66-NH2@MIP.

Bisphenol A poses persistent contamination hazards in dairy matrices, yet the molecular mechanisms underlying bisphenol A-induced metabolic disruption and homeostatic remodeling in animal-derived foods remain insufficiently elucidated. This study integrated untargeted metabolomics and lipidomics with the rational design of UiO66-NH2@MIP to mechanistically investigate bisphenol A-driven perturbations and enable selective adsorptive decontamination in goat milk. Multivariate statistical analysis revealed dose-dependent alterations in metabolomic and lipidomic profiles, with significant pathway enrichment in unsaturated fatty acid biosynthesis and glycerophospholipid metabolism. In view of the insufficient recognition ability of broad-spectrum adsorbents in complex systems and harsh reaction conditions of traditional MOF material synthesis, the optimized UiO66-NH2@MIP at room temperature under imprinting condition with BPA/APTES/TEOS molar ratio of 1:1:6 exhibited Langmuir-type monolayer adsorption with a maximum capacity of 17.61 mg/g, rapid equilibrium within 30 min, and favorable thermodynamics, indicating a spontaneous exothermic process governed predominantly by physical interactions. Method validation demonstrated satisfactory recoveries of 98.99%-118.71% from spiked goat milk samples with detection limits as low as 0.1 μg/kg. These findings advance mechanistic understanding of bisphenol A-induced metabolic alterations in dairy systems and establish a technically robust reusable adsorbent for efficient hazardous endocrine disruptor remediation in complex animal-derived food matrices.