Developing anti-inflammatory mineral trioxide aggregate as dental implant crown cement to reduce peri-implantitis incidence.

BACKGROUND/PURPOSE: Dental resin cement residue around periodontal tissue is one of the causes of peri-implantitis. Severe cases may cause the implant to loosen or fall off. Therefore, the goal of this study was to modify mineral trioxide aggregate as an anti-inflammatory dental implant crown cement (ICC). MATERIALS AND METHODS: The effects of deionized water solution (Daq), hydroxyapatite solution (Haq), and calcium chloride solution (Caq) on the setting time, compressive strength, adhesion strength, and biocompatibility of ICC were evaluated. One-way analysis of variance (ANOVA) was performed for each analysis to determine differences (P< 0.05) between experimental groups. RESULTS: The surface microstructure showed that the addition of Haq and Caq contributes to the binding between ICC particles. Surface element analysis showed that Haq addition increased the Ca ion content. Setting time results demonstrated that compared to Daq, Caq and Haq accelerated the final setting time by 46.5% and 34.7% respectively (P< 0.05). The compressive strength of Caq was 35.1% and 13.4% higher than those of Daq and Haq, respectively (P< 0.05). The adhesion strength results of the three ICC groups revealed that the resin cement had the same effect (P> 0.05). Biocompatibility and scavenging activity tests showed that ICC was superior to resin cement. CONCLUSION: ICC combined with Caq can shorten the setting time, improve compressive strength, increase biocompatibility, and reduce the possibility of inflammation. Therefore, the ICC system combined with Caq may serve as an alternative to dental resin cements.