Angela Halstead, Chinye Nwokolo, Stella G. Hoft, Jinsheng Yu, Lifei Zhu, Brendan Tuley, Nancy Vargas, RuiRui Liu, Francisco Victorino, Simrin Phatak, Wandy L. Beatty, Chun‐Kan Chen, Richard J. DiPaolo, Paul F. Cliften, Tarin M. Bigley, José B. Sáenz
BACKGROUND & AIMS: Recent evidence suggests that endogenously derived double-stranded RNA (dsRNA) impacts multiple cellular processes, although its role in epithelial injury remains understudied. We previously identified the response to dsRNA as the most upregulated pathway across 2 distinct murine models of spasmolytic polypeptide-expressing metaplasia (SPEM), a critical pre-neoplastic transition in the progression to gastric cancer. The aim of this study was to define how dysregulation of the dsRNA response within gastric epithelium impacts gastric pre-neoplasia. METHODS: mice, defective in type I and type III IFN signaling, respectively, were characterized. RESULTS: stomachs. CONCLUSIONS: Our new genetic model implicates ADAR1-mediated dsRNA signaling in gastric pre-neoplasia.