Jennifer von Stein, Philipp von Stein, Karl‐Patrik Kresoja, Vera Fortmeier, Christoph Pauschinger, Wolfgang Rottbauer, Mohammad Kassar, Bjoern Goebel, Paolo Denti, Paul Achouh, Tienush Rassaf, Manuel Barreiro-Perez, Peter Boekstegers, A. Ruck, Monika Zdanyte, Marianna Adamo, Flavien Vincent, Philipp Schlegel, Sebastian Rosch, Mirjam G. Wild, Christian Besler, Stefan Toggweiler, Stephanie Brunner, Julia Grapsa, Tiffany Patterson, Holger Thiele, Tobias Kister, Giuseppe Tarantini, Giulia Masiero, Marco De Carlo, Alessandro Sticchi, Fabian Voß, Amin Polzin, Antonio P. Rubbio, Francesco Bedogni, Thorald Stolte, Thomas Nestelberger, Tomás Benito González, Enrique Sánchez-Muñóz, Martin J. Swaans, Leo Timmers, Mathias H. Konstandin, Eric Van Belle, Marco Metra, Tobias Geisler, Rodrigo Estévez-Loureiro, Amir Abbas Mahabadi, Nicole Karam, Francesco Maisano, Philipp Lauten, Fabien Praz, Mirjam Keßler, Daniel Kalbacher, Volker Rudolph, Philipp Lurz, Roman Pfister, David J. Cohen, Juan F. Granada, Rebecca T. Hahn, Jörg Hausleiter, L Stolz, Christos Iliadis, Stephan Baldus, Ralph-Stephan von Bardeleben, Karl-Philip Rommel, Felix Rudolph, Hazem Omran, Muhammed Gerçek, Sebastian Ludwig, Benedikt Koell, Leonhard-Moritz Schneider, Matthias Gröger, Dominik Felbel, Carsten Salomon, Harald Lapp, Quentin de Baynast, Alain Berrebi, Florian Schindhelm, Berenice Caneiro-Queija, Julio Echarte-Morales, Andreas Goldschmied, Edoardo Pancaldi, Daniela Tomasoni, Matteo Pagnesi, Natacha Rousse, Samy Aghezzaf, Shirin Bakhtari, Norbert Frey, Martin Kraus, Dirk Westermann, Christian Restle, Federico Arturi, Andrea Panza, Matteo Mazzola, Cristina Giannini, Philipp M. Doldi, Thomas J. Stocker, Ludwig T. Weckbach, Kaspar Volz, Julia Novotny
BACKGROUND: N-terminal pro-B-type natriuretic peptide (NT-proBNP) is an established marker of myocardial stress, yet its prognostic role in tricuspid valve transcatheter edge-to-edge repair (T-TEER) for tricuspid regurgitation (TR) remains unclear. OBJECTIVES: The aim of this study was to evaluate the prognostic value of baseline NT-proBNP and its early postprocedural trajectory after T-TEER. METHODS: Patients undergoing T-TEER with available baseline NT-proBNP measurements in the EuroTR (European Registry of Transcatheter Repair for Tricuspid Regurgitation) registry were analyzed. NT-proBNP was evaluated continuously and by tertiles, with longitudinal changes assessed when serial measurements were available. Endpoints were the 2-year composite of all-cause mortality or first heart failure hospitalization, changes in NT-proBNP, symptomatic alleviation, and residual TR. RESULTS: increase: 0.63; 95% CI: 0.48-0.84; P < 0.001). Both baseline NT-proBNP and higher than expected 30-day levels relative to baseline were independently associated with higher subsequent risk for the primary endpoint. CONCLUSIONS: Baseline NT-proBNP was independently associated with 2-year mortality or heart failure hospitalization after T-TEER. Early postprocedural NT-proBNP trajectories provided incremental prognostic information and may identify patients at increased risk.