C Davidson, Rebecca T. Hahn, J Hunter Mehaffey, David J. Cohen, Sean Pinney, Suzanne V. Arnold, Lukas Stolz, Matthew Lawlor, JoAnn Lindenfeld, Michael I. Brener, Aasim Afzal, R. Stephen Smith, Roseann White, Sreekanth Vemulapalli, Maria Alu, Emily Cohen, Kiera Regan, Anna Sannino, Sammy Elmariah, Ernest Spitzer, Eugene H. Blackstone, Philipp Lurz, Brian R. Lindman, Yan Topilsky, Suzanne J. Baron, Scott Chadderdon, Omar Khalique, Gilbert H.L. Tang, Maurizio Taramasso, Paul Grayburn, Luigi Badano, Jonathon Leipsic, Stephan Windecker, B Redfors, Josep Rodés-Cabau, Ori Ben‐Yehuda, Gorav Ailawadi, Michael J. Mack, M Leon, Vinay Badhwar, Jörg Hausleiter
The first Tricuspid Valve Academic Research Consortium publication standardized definitions of disease etiology and severity, as well as standardized endpoints for trials to address the knowledge gaps related to identification and management of patients with tricuspid regurgitation. Based on randomized trials comparing transcatheter tricuspid valve intervention with optimal medical therapy, transcatheter edge-to-edge repair and tricuspid valve replacement were approved by the U.S. Food and Drug Administration and received CE Mark. These technologies represent a major step forward for patients with severe symptomatic tricuspid regurgitation and transcatheter tricuspid valve intervention. This second chapter of the Tricuspid Valve Academic Research Consortium focuses on defining specific trial design and endpoint options for comparisons of emerging technologies, tricuspid valve surgery, and medical therapy.