Beyond immunity: hematopoietic involvement in nonhematological inborn errors of immunity.

Inborn errors of immunity (IEIs) are a group of disorders caused by defects in the immune system. Emerging evidence indicates that dysregulated interferon (IFN) signaling can perturb hematopoietic stem cells in nonhematological IEIs. This forum examines the role of IFNs in regulating hematopoiesis to inform prognosis and therapeutic strategies in IEI.