Noma Assad, Hugo Nordin, Alexis nguyen, Claire Oddos, Gwendolyn Marguerit, Lalou delgado, Isabelle Schiltz, Adrien Picod, Maxime Zalc, Antoine beurton, Marion tanguy, Pierre-emmanuel rautou, Malha Sadoune, Evelyne Polidano, Jean-Marie Launay, Karine santos, Nicolas Vodovar, Alexandre Ouattara, Damien logeart, Amélie Calmont, Alexandre mebazaa, Feriel Azibani
mice, cDPP3 increase was comparable to stressed WT mice. DPP3 injection in WT mice induced cardiac neutrophil infiltration. Extracellular vesicles from plasma and bone marrow carried only a minimal fraction of DPP3, indicating mainly soluble release. These results reveal bone marrow-derived cells as a main driver of cDPP3 release under stress and provide a foundation to optimize its use as a biomarker and therapeutic target.