Factors influencing the proliferation of keratinocytes in psoriasis

The pathogenesis of psoriasis is extremely complex, and abnormal proliferation of keratinocytes (KCs) is one of its key pathological features. During the disease process, multiple factors can induce KC proliferation. This article reviews the mechanisms by which inflammatory cytokines, immune microenvironment, microbiome, epigenetics, metabolism, and the autophagy influence KC proliferation, aiming to provide insights for further research into the pathogenesis of psoriasis and the development of precise clinical treatments.