Yuxian Kuai, Wen Xu, Xue Wang, Xiaodan Xu, Pintong Huang
evidence reveal that ultrasound-mediated gene transfection with Fuc-pPGC-1α-GVs could ameliorate renal IRI by rescuing the function of ECs, decreasing immune cell infiltration, and alleviating renal tubular injury. Mechanistically, overexpressed PGC-1α in injured renal ECs promotes mitophagy and inhibits ROS production by upregulating BNIP3, BNIP3L, and SOD2. This study provides a promising strategy for the early and efficient treatment of renal IRI.