Scott M. Matson, Linh T. Ngo, Yui Sugawara, Veani Fernando, Claudia Lugo, Angela Kaczorowski-Worthley, Imaan Azeem, A. Marc Harrison, Alex Alsup, Emily Schueddig, Devin C. Koestler, Michaella J. Rekowski, Paul J. Wolters, Joyce S. Lee, Michael P. Washburn, Joshua J. Solomon, M. Kristen Demoruelle
= 52). Higher BALF levels of extracellular DNA, DNA-myeloperoxidase complexes, calprotectin, and neutrophil elastase predicted worse survival (hazard ratios: 1.79-2.19) and correlated with reduced lung function. These results identify neutrophil degranulation as a compartment-specific mechanism of lung injury in IPF that may guide therapeutic development and risk stratification.