Ginsenoside Rh2 alleviates acne-associated inflammation for cosmetic applications

Acne is a chronic inflammatory skin disease closely associated with aberrant immune activation and inflammatory cell recruitment. In this study, acne-related expression profile data from the GSE53795 dataset were used to identify differentially expressed genes between inflammatory acne lesions and non-lesional skin tissues. Functional analysis indicated that SELE, a cell adhesion molecule involved in leukocyte adhesion, rolling, and migration, may play an important role in acne-related inflammation. Further transcription factor prediction suggested that RELA/NF-κB p65, a key regulator of inflammatory responses, may regulate SELE and related inflammatory genes. Given the anti-inflammatory, antioxidant, and immunomodulatory activities of Panax notoginseng (P. notoginseng) saponins, this study further discusses the potential application of P. notoginseng as a natural active ingredient in acne-prone skincare. With the increasing market demand for natural-derived skincare ingredients, P. notoginseng shows promising value for the development of soothing, anti-inflammatory, and functional cosmetic raw materials, providing a new strategy for its high-value utilisation.