Anaïs. Compositeur présumé Roger, Tiphaine Fohrer, Ugo Mardelle, Isaac Thomas, Sara Teimouri Nezhad, Surbhi Gupta, Alissa Dory, Vidthiya Jeyanathan, Andisheh Liaghat, Julie Mielle, Hakim Medjouel Khlifi, Jérémy C. Santamaria, Elena Brunet, Jordi Gouilly, Bertrand Escalière, Ninon Bretaud, Théo Crosson, Pierre-Vincent Barbon, Noushin Mossadegh-Keller, Magali Irla, Sam Basta, Achille Broggi, Pierre Milpied, Naina Gour, Vincent Feuillet, Guillaume Hoeffel, Xinzhong Dong, Eva Kaufmann, Ana Reynders, Sébastien Talbot, Aziz Moqrich, Sophie Ugolini
sensory neurons limited neutrophil infiltration through the Mas-related G protein-coupled receptor member A1 (MRGPRA1) receptor and promoted skin healing, revealing an unexpected anti-inflammatory role for this neuropeptide. In infected DRGs, a TAFA4-interleukin (IL)-10 pathway promoted the resolution of inflammation after viral clearance. Together, these neuroimmune regulatory pathways reduced the detrimental impact of the infection on host fitness without directly altering pathogen elimination, revealing how the sensory nervous system has developed several mechanisms to promote disease tolerance.