Cameron L R Mattingly, Ariana R. Jimenez, M Elliott Williams, Kirsten Kost, Laurel A. Lawrence, Thien Duy Chen, Sarah Michalets, Jenna L Lobby, Yixel Soto-Vázquez, Kathryn M. Moore, Sakeenah L. Hicks, Shamika Danzy, Jennifer L. Elliott, Christopher D. Scharer, Alison Swaims-Kohlmeier, Anice C. Lowen, Aneesh K. Mehta, Jacob E. Kohlmeier
Trm cell activation. In air-liquid interface cultures modeling influenza infection of the lung, rapid IFNγ signaling was necessary and sufficient to activate antiviral pathways in stratified epithelium and protect against infection. Thus, lung Trm cells coordinate early mucosal defense through rapid IFNγ-driven epithelial programming to restrict respiratory virus propagation in humans.