Correlation analysis of Serum FGLP1, UACR and the risk of heart failure in patients with type 2 diabetes.

BACKGROUND: To explore the correlations between serum FGLP1 (Fibrinogen-like protein 1 C-terminal peptide) levels, the urine albumin-to-creatinine ratio (UACR) and left ventricular diastolic dysfunction (LVDD) in elderly patients with type 2 diabetes mellitus (T2DM). METHODS: From August 2023 to August 2025, 256 elderly patients with T2DM who were admitted to our hospital were selected as the case group, and 120 healthy individuals who underwent physical examinations were selected as the control group. In accordance with the diagnostic criteria for LVDD, T2DM patients were divided into a disorder group (n=70) and a nondisorder group (n = 186). Single-factor analysis, multivariate logistic regression, and Spearman correlation analyses were performed to examine the relationships among serum FGLP1 levels, UACRs, and LVDD in T2DM patients, and receiver operating characteristic curves were used to evaluate the ability of serum FGLP1 levels and urine UACRs to predict LVDD.