Hoa Nguyen Thi, Hoa Nguyen Thi, Nguyen Quoc Phuong, Phạm Ngọc Thạch, Tran Van Giang, Hoang Thi Lan Huong, Trinh Huu Tung, Van Dinh Trang, Tran Van Bac, Ninh Thi Ngoc, Luong Huong Giang, Doan Duy Thanh, Dong Phu Khiem, Dao Thanh Hai, Hoang Thuy Trang, Nguyen Thi Ha, Nguyen Thi Ha, Mai Van Tuan, Tat Dung Nguyen, Van Binh Tran, Thu Le Thi, Phuong Phan Thi, Thu Le Thi, Phuong Phan Thi, Van Long Hoang, Bach Oanh Nguyen Thi, Xuan Hien Nguyen, Thanh Dat Nguyen, Xuan Hien Nguyen, Huong Nguyen Thi, Huong Nguyen Thi, Quynh Thi Phan Le, Quang Nhat Tran, Duc Huy Tran, Thai Duy Duong, Quynh Anh Nguyen Thi, Nguyen Minh Ngoc, Kim Anh Nguyen Thi, Quynh Anh Nguyen Thi, Duc Loi Pham Thi, Minh Thao Ho Thi, Nhieu Nguyen Thi, Duc Loi Pham Thi, Minh Thao Ho Thi, Nhieu Nguyen Thi, Hong Phuong Trinh Thi, Hong Phuong Trinh Thi, Bich Kim Tran Thi, Thanh Thien Nguyen, Minh Uyen Nguyen Cao, Ngoc Anh Le, Bich Kim Tran Thi, Kieu Giang Ho, Lan Phuong Nguyen Thi, The Trung Bui, Thuy Trang Nguyen Thi, Vu Tien Viet Dung, Prapass Wannapinij, Vanapol Chamsukhee, Naomi Waithira, Tamalee Roberts, Clare L. Ling, Jill Hopkins, Paul Turner, H Rogier van Doorn
OBJECTIVES: ACORN (A Clinically-Oriented Antimicrobial Resistance Surveillance Network) integrates antimicrobial resistance (AMR) surveillance with clinical data in hospitals across low- and middle-income countries. We describe ACORN2 data from Vietnam and compare findings with existing national surveillance data. METHODS: Hospitalized patients receiving intravenous antibiotics were enrolled from selected wards in three national hospitals. Infections were classified as community-acquired (CAI), healthcare-associated (HCAI), or hospital-acquired (HAI). Microbiological data were deduplicated to the first isolate of each bacterial species per sample types within each infection episode. Pathogen distribution and resistance patterns were analyzed by hospital, infection origin, and sample type. RESULTS: Among 5449 infection episodes, 2817 were CAI, 1615 HCAI, and 1017 HAI. Escherichia coli and Staphylococcus aureus predominated in sterile samples, while Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae were most frequent in non-sterile samples. A. baumannii and P. aeruginosa were common in HCAI and HAI. Resistance to third-generation cephalosporins and carbapenems was markedly higher in HCAI and HAI than CAI, with widespread carbapenem resistance in A. baumannii. Overall AMR levels exceeded those reported in previous national surveillance data. CONCLUSION: ACORN2 demonstrates a high burden of AMR in Vietnam, particularly in healthcare- and hospital-acquired infections, underscoring the value of clinically oriented surveillance to inform treatment and stewardship policies.