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◆ Frontiers in human neuroscience2026-01-01

Hidden in plain sight: verbal declarative memory effects of exercise are eight times larger than aggregate estimates suggest.

Mengxuan Tian, Sainyu Guo

一句话结论 · In one sentence

The null aggregate memory effect masks a meaningful signal for verbal declarative memory. The findings support domain-specific exercise prescriptions: for hippocampus-dependent verbal memory, moderate-intensity aerobic exercise represents an evidence-supported strategy for enhancing retention.

原始摘要(英文原文)· Original abstract
OBJECTIVE: A recent meta-meta-analysis concluded that the average effect of exercise on memory is near zero after correcting for publication bias (SMD = 0.027). We tested whether this null finding reflects excessive aggregation rather than a genuine absence of effect. METHODS: We conducted a focused reanalysis a publicly available meta-meta-analytic database, applying a theoretically motivated outcome reclassification protocol to isolate verbal declarative memory (VDM). From 2,239 effect-size estimates spanning 215 meta-analyses, k = 37 VDM-specific estimates were synthesized using a random-effects model. Publication bias was assessed via Egger's test, PET-PEESE, and trim-and-fill. RESULTS: The pooled effect was g = 0.216 [95% CI (0.075, 0.357), p = 0.003], approximately eight times larger than the aggregate estimate of 0.027. Moderate heterogeneity was observed (I 2 = 56.1%), with no significant funnel plot asymmetry (p = 0.458). Aerobic exercise produced the most robust benefit (g = 0.229, k = 27). CONCLUSION: The null aggregate memory effect masks a meaningful signal for verbal declarative memory. The findings support domain-specific exercise prescriptions: for hippocampus-dependent verbal memory, moderate-intensity aerobic exercise represents an evidence-supported strategy for enhancing retention.
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Hidden in plain sight: verbal declarative memory effects of exercise are eight times larger than aggregate estimates suggest. — 科研速览 Science Skim