Hexagram prism structure composed of hyaluronic acid and hydrolyzed collagen as a dissolvable physical micro-disruption platform for topical delivery of hydrophilic cargos.

Meltryx is a non-insertive and rolling-based particle system developed to transiently enhance topical delivery of cosmetics while preserving skin integrity. Composed of hyaluronic acid and hydrolyzed collagen, Meltryx possesses a hexagram prism structure (1.5 mm in diameter and height) with six microprojection arms of approximately 375 μm in length. Although it fully disintegrates within 1.5 min in aqueous environments, Meltryx maintains sufficient mechanical strength to induce controlled micro-perturbation of the stratum corneum (SC) during application. Its star-shaped geometry enables continuous rolling across the skin surface without complete tissue embedding and minimizing invasiveness. To evaluate penetration enhancement, Meltryx was topically applied to porcine skin under varying particle numbers, rolling cycles, and mechanical loads. Treatment with five Meltryx particles, ten rolling cycles, and 1 kg load significantly increased niacinamide (as a hydrophilic model chemical) accumulation in the mid-to-deep SC layers and enhanced penetration compared with solution (control) group. These findings suggest that Meltryx generates transient micro-channels that expand diffusion pathways, enabling deeper and sustained delivery of hydrophilic actives. Meltryx represents a minimally invasive and user-friendly physical penetration enhancer for skin healthcare applications with topical formulations.