Contribution of polycystic kidney disease to the development of chronic renal dysfunction in cats.

Polycystic kidney disease (PKD) is a hereditary disorder characterized by progressive renal cyst formation, leading to compromised kidney function and an increased risk of chronic kidney disease (CKD). This prospective, 18-month longitudinal study evaluated diagnostic and prognostic markers in 12 PKD-affected cats, utilizing ultrasound imaging alongside biochemical analysis. The study documented a 14.00% increase in cyst volume, a 7.00% enlargement in kidney length, and significant elevations in plasma creatinine, phosphorus, and blood urea nitrogen levels, underscoring their correlation with disease progression. Hematological analysis revealed progressive anemia associated with advanced CKD stages, further outlining the systemic impact of PKD. These findings emphasize the progressive nature of CKD in cats with PKD, despite diligent care provided by pet owners and veterinarians. Also, the importance of routine sonographic evaluation along with hematological and biochemical assessments is highlighted in our study to enhance early detection and improve outcomes in feline PKD. Future longitudinal studies with expanded cohorts are essential to validate these findings and refine diagnostic criteria for PKD-associated CKD.