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◆ European urology oncology2026-09-21

Triplet Therapy in Metastatic Clear Cell Renal Cell Carcinoma: Time to Abandon Empiric, Biomarker-unselected Intensification?

Javier Molina-Cerrillo, Victoria Gómez Dos Santos, Teresa Alonso-Gordoa

一句话结论

The priority now is validated biomarkers for patient selection and mechanistically distinct therapies, rather than more unselected triplets.

原始摘要(原文)
Adding a third drug to standard immunotherapy combinations can prolong disease control but has not yet improved survival benefit and, when used empirically, increases toxicity. The priority now is validated biomarkers for patient selection and mechanistically distinct therapies, rather than more unselected triplets.
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Triplet Therapy in Metastatic Clear Cell Renal Cell Carcinoma: Time to Abandon Empiric, Biomarker-unselected Intensification? — 科研速览 Science Skim