Predicting of Nano Cerium/Hydroxyapatite Efficiency Against γ- Irradiation Induced Heart Failure in Albino Rats.

The study was conducted to investigate the therapeutic potential of nano cerium hydroxyapatite (nCe/HAp) on γ-irradiation (IR) induced cardiac failure in male rats. Cardiac failure was induced by exposure to 9 Gy of γ-radiation. The nanocomposite nCe/HAp was administered at a dose of 50 mg/kg b.w. intravenously. The levels of oxidative status, heart enzymes, troponin I (cTnI), total creatine kinase (CK), creatine phosphokinase isoenzyme (CK-MB), and lactate dehydrogenase (LDH) were measured, in addition to immune status, by measuring the levels of nuclear factor kappa B (NF-kB), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and C-reactive protein (CRP). Pathological analysis of heart tissue was undertaken for all animals. The results revealed the effectiveness of nCe/HAp in ameliorating most of the examined parameters by significantly elevating the GSH and SOD activity levels. On the other side, there was a significant decline in the serum NO, MDA, cTnI, NF-kB, CK, CK-MB and LDH levels upon treatment. Microscopic evaluation of tissue samples confirmed the biochemical outcomes and the variance between the control and the other treated groups. In conclusion, nCe/HAp succeeded in preventing heart damage to a considerable degree, and paves the way for Ce/HAp nanocomposites as promising effective candidates for mitigating radiation treatments.