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◆ ESMO Open2026-03-17· Medicine

223MO Five-year outcomes of participants with pathological complete response (pCR) enrolled in the KEYNOTE-671 trial of perioperative pembrolizumab (pembro) in early-stage NSCLC

M. Majem, M. Garassino, C. Dooms, E. Eigendorff, G.L. Martinengo, O. Bylicki, D. Rodriguez Abreu, S. Novello, E. Nadal, A. Lowczak, D. De Almeida Matias, A. Luft, B. Mennecier, A. Rittmeyer, E. Jensen, S. Keller, Ayman Samkari, J. Spicer

原始摘要(英文原文)· Original abstract
In the phase 3 KEYNOTE-671 study of early-stage NSCLC, perioperative pembro plus neoadjuvant chemotherapy (chemo) significantly improved event-free survival (EFS), overall survival (OS), major pathological response, and pCR vs neoadjuvant chemo. EFS was prolonged in exploratory analyses of participants (pts) who achieved pCR (HR, 0.33; 95% CI, 0.09–1.22). We report efficacy results in pts with pCR from KEYNOTE-671 after 5 years of follow-up.
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223MO Five-year outcomes of participants with pathological complete response (pCR) enrolled in the KEYNOTE-671 trial of perioperative pembrolizumab (pembro) in early-stage NSCLC — 科研速览 Science Skim