M. Amin, Md Saydur Rahman
Pharmaceutical contamination in soil and air has become a critical environmental concern due to its widespread sources, complex behavior, and long-lasting ecological impacts. This review comprehensively explores the presence, fate, and effects of pharmaceutical compounds in soil, highlighting their entry routes, environmental persistence, and biological consequences. Pharmaceuticals infiltrate terrestrial and aquatic environments through various pathways, including agricultural application, pharmaceutical manufacturing waste, sewage sludge, hospital and household discharges, irrigation with contaminated water, and atmospheric deposition. A wide range of drug classes, such as antibiotics, analgesics, non-steroidal anti-inflammatory drugs, antidepressants, anticancer drugs, and hormones, have been identified in both soil and air matrices worldwide. The review highlights key processes that affect pharmaceutical behavior in the environment, including adsorption of soil particles, degradation, leaching into deeper layers, airborne deposition, and bioaccumulation in organisms. These processes significantly influence their environmental mobility and toxicity. The presence of pharmaceuticals alters soil microbial communities, reduces biodiversity, and disrupts plant growth and crop productivity. Furthermore, terrestrial animals and wildlife exposed to airborne pharmaceutical residues face physiological and behavioral disturbances, raising significant ecological and health concerns. This review also highlights the urgent need for interdisciplinary research to better understand the dynamics of pharmaceuticals in soil and their long-term implications for ecosystem health and sustainability. It also recommends innovative strategies to minimize contamination, including advanced waste-treatment technologies and sustainable pharmaceutical practices. Overall, the review provides valuable insights into an underexplored dimension of pharmaceutical pollution, aiming to inform future policy development and environmental protection efforts. • Pharmaceutical contamination in soil and air has become a critical environmental concern. • Pharmaceuticals in air and soil are an increasing threat to terrestrial and microbial communities. • Most common drugs are antibiotics, analgesics, NSAIDs, antidepressants, anticancer drugs. • This article critically reviews the different pharmaceutical drugs in soil and air. • This article also highlights the urgent need for interdisciplinary research for ecosystem health.