科研速览 · Science Skim继续刷下去 · Keep skimming →
◆ EBioMedicine2026-07-31· Biology

Interfering with innate immunity: type I IFNs and avian influenza susceptibility

Stuart G. Tangye, S. Cindy

原始摘要(英文原文)· Original abstract
Type I interferons (IFNs) are central to early antiviral innate immunity, being produced rapidly by diverse cell types to restrict viral replication.1 The importance of type I IFNs in host defence against infections became apparent in studies of mice treated with neutralising antibodies (Ab) against type I IFN, or rendered genetically deficient for the type I IFN receptors (IFNα/βR). Infection of these mice with a wide range of viruses resulted in severe morbidity and/or mortality.2 In contrast, control of bacterial or other non-viral pathogens in IFNα/βR-deficient mice was largely intact, while infection of mice lacking the type II IFNγR with these viruses was mild.
读原文 · Read the paper ↗

AI 追问PRO

登录后使用 AI 追问

讨论区

登录后参与讨论

相关论文 · Related

Interfering with innate immunity: type I IFNs and avian influenza susceptibility — 科研速览 Science Skim