Modulation of OGG1 enzymatic activity by the cellular machinery – have all the boxes been ticked?

8-oxoguanine DNA glycosylase 1 (OGG1) is the key enzyme responsible for identifying and removing 8-oxoguanine (8-oxoG), the most common oxidative lesion in DNA. While its central role in base excision repair (BER) is well established, OGG1 also plays important roles in transcriptional regulation, cell signalling, and inflammation. As its involvement in these pathways is increasingly recognised, a cohesive overview of how OGG1 activity is regulated within the cell is needed. This review summarises the current understanding of OGG1 regulation at multiple levels, through post-translational modifications (PTMs), dynamic protein-protein interactions, and changes in expression levels. We highlight research on the action of reversible PTMs such as phosphorylation, glycosylation, and acetylation, and emphasise the remaining gaps in our knowledge. OGG1 presents a compelling target for small-molecule modulation with potential therapeutic applications in cancer, inflammatory disorders, and age-related diseases. Finally, we discuss how ubiquitination and the circadian rhythm impact overall OGG1 abundance and consider their implications for therapeutic strategies.