Maud Gendard, Philippe Seksik, Carmen Stefanescu, Antoine Meyer, Maria Nachury, Stéphane Nancey, Guillaume Savoye, Matthieu Allez, David Laharie, Mélanie Serrero, Denis Franchimont, Nicolas Mathieu, Mathurin Fumery, Lucine Vuitton, Stéphane Nahon, Cyrielle Gilletta, Cléa Rouillon, Alexandre Nuzzo, Catherine Le Berre, Bénédicte Caron, Anthony Buisson, Morgane Amil, Maëva Charkaoui, Guillaume Cadiot, Ludovic Caillo, Marion Simon, Cathérine Reenaers, Xavier Hébuterne, Laurianne Plastaras, Călina Atanasiu, Sandy Kwiatek, Mathieu Uzzan, Anne-Laure Pelletier, Alban Benezech, Mathias Vidon, Felix Goutorbe, Sophie Geyl, Christophe Cellier, Céline Montuclard, Driffa Moussata, Romain Altwegg, Aurélien Amiot
BACKGROUND AND AIMS: The impact of Physical activity (PA) on the activity of inflammatory bowel disease (IBD) remains unclear. PATIENTS AND METHODS: A descriptive cross-sectional study included consecutive patients with Crohn's disease (CD), ulcerative colitis (UC). PA was assessed using the short International Physical Activity Questionnaire. PA was classified as low, medium or high PA. PA was also assessed according to WHO recommendations. IBD activity was evaluated using PRO-2, while IBD-related disability was assessed with the IBD-disk questionnaire. RESULTS: Among a total of 2514 patients (1715 CD), only 28.8% met the WHO recommendations on PA (49.8% had low PA, 35.2% had medium PA, and 15.0% had high PA). Medium and high PA levels were associated with a higher rate of patient-reported clinical remission in patients with CD (OR 1.30 [1.08-1.57] for medium PA, and 1.33 [1.03-1.72] for high PA vs. low PA; p-trend=0.02) but not in those with UC. Higher PA levels were associated with less IBD-related disability in both CD, and UC. CONCLUSION: In a large cohort of IBD patients, moderate and high PA was associated with higher rates of clinical remission in patients with CD and lower IBD-related disability in both CD and UC patients.