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◆ Diagnostic microbiology and infectious disease2026-07-28

Limitations of PCR-based detection of Neisseria meningitidis: The potential influence of non-encapsulated strains on diagnostic failure.

Miguel Fernández-Huerta, Eduardo Lagarejos, Iballa Horcajada, Laura Florén-Zabala, Laura Alonso-Acero, Laura Iglesias-Llorente, Rosa Pedraza-Merino, Estefanía Águila, Raquel Abad, Josep Roca-Grande, Juan José González-López, Ana Bordes-Benítez

原始摘要(英文原文)· Original abstract
Bacterial meningitis is a life-threatening disease, requiring timely diagnosis and rapid onset of antimicrobial therapy. Herein, we describe a case of culture-positive meningococcal meningitis caused by a non-encapsulated strain in an immunocompetent individual. Notably, this case yielded negative results using commercially-available real-time PCR assays.
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Limitations of PCR-based detection of Neisseria meningitidis: The potential influence of non-encapsulated strains on diagnostic failure. — 科研速览 Science Skim