HOF-triggered amorphization of Zr-porphyrin MOF as a high-performance extraction sorbent for ultrasensitive monitoring of bisphenols in instant noodle matrices.

Bisphenols (BPs) are persistent endocrine-disrupting food contaminants whose trace-level monitoring in complex matrices such as instant noodles is hampered by low concentrations and matrix interference. We report a hydrogen-bonded organic framework (HOF)-triggered amorphization strategy to convert the zirconium-porphyrin MOF PCN-224 into a series of amorphous TATB-HOF/PCN-224x (ATPx) composites for dispersive solid-phase extraction (dSPE) of BPs. The optimized ATP5.0 had a hierarchical meso‑macroporous structure (150.17 m²/g) with abundant active sites. Coupled with HPLC-UV, the dSPE method gave linear ranges of 0.5-1500 ng/mL (R² = 0.9972-0.9990), LODs of 0.134-0.946 ng/mL, RSDs ≤ 6.28% (n = 3), and recoveries of 72.2-118.2% in spiked instant noodles. Isotherm/kinetic modelling and spectroscopic evidence indicated heterogeneous multilayer chemisorption driven by π-π stacking, hydrogen bonding, and weak Zr-O coordination. This work provides a sensitive, low-cost dSPE platform for BP monitoring in food matrices and a general HOF-mediated route to amorphous MOF sorbents.