The rational design of coordination-driven supramolecular artificial enzymes: From catalysis to biomedicine

Self-assembled coordination architectures are emerging as powerful platforms for creating artificial enzymes that emulate the structural and functional complexity of natural biocatalysts. By combining well-defined cavities, tunable host-guest interactions, and catalytic control within confined nanoscale spaces, these systems offer unique opportunities for advancing sustainable catalysis, molecular recognition, and biomedical innovation. In this perspective, we highlight recent advances in the design and function of coordination-driven artificial enzymes, focusing on how metal-organic architectures (MOAs) can be engineered to stabilize reactive intermediates, direct substrate selectivity, and respond to external stimuli. We outline the principles behind these supramolecular systems and explore their growing potential in both industrial and therapeutic contexts.