Kendrick Nguyen, Monika Quackenbush, Sara Basbous, Haley Rodriguez, Georgia Lattanzi, Elsie Quansah, Chynna Bowman, Sammy Weiser Novak, Daniela Boassa, Jingting Yu, Taylor Ozbun, Asona Lui, Aatish Thennavan, Peter Watson, April Wehner, Daniel Hollern
B cell responses to cancer are critical to patient survival and response to therapy. Yet, the knowledge as to how B cells can elicit anti-tumor immunity remains incomplete. We identify that CD40 pathway activation in B cells in the presence of high tumor mutation burdens activates an anti-tumor B cell response. Significantly, our study shows that CD40-stimulated B cells drive tumor infiltration, organization, and activation of cytotoxic function in CD8+ T cells. These results provide key advances in the mechanistic regulation and function of B cell and CD8+ T cell responses to cancer.