Alia Sajani, Evelien Schaafsma, Walburga Croteau, Mohamed ElTanbouly, Elizabeth C. Nowak, Chao Cheng, Christopher M. Burns, Mary Jo Turk, Randolph J. Noelle, J. Louise Lines
This study describes the transcriptional heterogeneity of murine and human naive CD4 + T cells as comprising multiple discrete clusters that impact CD4 + T cell fate and trajectories. Naive CD4 + T cells experiencing inflammatory environments exhibit an altered transcriptional state that biases their differentiation trajectories.