Nora John, Thomas Fleming, Julia Kolb, Olga Lyraki, Sebastián Vásquez-Sepúlveda, Asha Parmar, Kyoohyun Kim, Maria Tarczewska, Pooja Gupta, Kanwarpal Singh, Fédérico Marini, Sumeet Pal Singh, Vasiliki Tsata, Sven Falk, Kristian Franze, Jochen Guck, Daniel Wehner
fibroblasts coordinate the resolution of the neutrophil-driven inflammation. Disruption of these inflammation dynamics alters the mechano-structural properties of the lesion microenvironment and inhibits regeneration and recovery of locomotor function. Thus, zebrafish fibroblasts possess a dual role in inducing and resolving inflammation, which are both required for regeneration. This establishes the biphasic inflammation control by fibroblasts as an important mechanism directing CNS regeneration.