Daniel J Silver, Chang Xu, Justin D Lathia
Scherer's century-old classification of expansive and infiltrative glioma growth remains foundational to neuro-oncology. In this issue of Cancer Cell, Hoefflin et al. use spatial RNA and protein profiling of IDH-mutant gliomas to reveal hypoxia and necrosis as organizing centers of expansive growth and white-matter tracts as guides and constraints on invasion.