Weijie Guo, Jingyun Luan, Xuejie Huang, Daniel Leon, Sophie Gang, Benjamin Nicholson, Breanna Bertacchi, Diana Bolotin, Mark W. Lingen, Alexander T. Pearson, Evgeny Izumchenko, Ari J. Rosenberg, Nishant Agrawal, Everett E. Vokes, Siwakorn Punyawatthananukool, Shuh Narumiya, Matthias Gunzer, Iván Ballesteros, Andrés Hidalgo, Yuxuan Miao
) signaling in TANs, which can disrupt the interferon response and prevent the interferon-induced anti-tumor functions in TANs. By fine-tuning the plasticity of neutrophils, tSCs shape neutrophil heterogeneity and sculpt a protective micro-niche to survive from immunotherapy and drive cancer relapse.