Current advances in stereoselective chemical O-glycosylation for the synthesis of glycans.

Stereoselective chemical glycosylation represents the key steps for the construction of structurally well-defined glycans and glycoconjugates, which are essential for interrogating their biological functions and developing carbohydrate-based medicines. This review highlights advances in the past two years in stereoselective O-glycosylation methodologies, including THF-modulated glycosylation, donor-derived auxiliary group-mediated glycosylation, catalyst-mediated glycosylation, and non-assisted aglycon transfer glycosylation.