Joey Verdijk, Tonia A.L. van Dijk-Schouten, Julia C.M. Pottkämper, Laurens A. van de Mortel, Freek ten Doesschate, Sven Stuiver, Maxime Chamberland, David Norris, M.J. van Putten, J. Hofmeijer, Guido A. van Wingen, Jeroen A. van Waarde
BACKGROUND: Electroconvulsive therapy (ECT) is effective in depression, but associated with postictal agitation. Mechanisms of postictal symptoms are largely unclear. We studied whether postictal symptoms are related to immediate postictal diffusivity changes. METHODS: In a randomized cross-over clinical trial, we acquired diffusion tensor imaging (DTI) scans before the ECT-course and three times immediately postictally in 22 patients. In this secondary analysis, mixed effects models and Generalized Estimating Equations were used to assess postictal changes in mean fractional anisotropy (FA) and mean diffusivity (MD), including relations with reorientation time and occurrence of postictal agitation. Additionally, with Tract-Based Spatial Statistics (TBSS), voxel-wise changes in the white matter (WM) skeleton were examined. RESULTS: , OR = 1.42, p = 0.04) in white matter. No significant associations were observed with baseline values of MD or FA. CONCLUSIONS: We show that postictal agitation is associated with brain-wide immediate postictal diffusivity changes, suggesting a clinically relevant role of changes in tissue microstructure shortly after an ECT-induced seizure.