Athanasia Metoki, Benjamin P Kay, Roselyne J Chauvin, Samuel R Krimmel, Anxu Wang, Philip N Cho, Julia Monk, Noah J Baden, Kristen M Scheidter, Scott Marek, Timothy O Laumann, Evan M Gordon, Nico U F Dosenbach, Deanna M Barch
Pubertal timing is associated with sex-specific patterns of brain functional connectivity during early adolescence, with greater heterogeneity and broader network involvement in females. These findings suggest that pubertal maturation contributes to early reorganization of functional brain networks, although these changes did not explain subsequent depressive symptoms.
BACKGROUND: Variation in pubertal maturation relative to same-age, same-sex peers (pubertal timing) has been linked to increased risk for depressive symptoms during adolescence. This developmental period is also characterized by substantial reorganization of functional brain networks. However, how pubertal timing relates to resting-state functional connectivity (rsFC) changes and depression risk remains unclear.
METHODS: We examined pubertal timing and rsFC associations in 9-11-year-old preadolescents from the Adolescent Brain Cognitive Development (ABCD) Study. Pubertal timing was estimated using a puberty age gap approach based on parent-reported physical development. Linear mixed-effects and Bayesian multilevel models were used to assess cross-sectional and longitudinal associations between pubertal timing and rsFC across large-scale functional brain networks. We also tested whether rsFC differences explained associations between pubertal timing and later depressive symptoms.
RESULTS: Earlier pubertal timing was associated with heterogeneous rsFC patterns, with stronger and more widespread effects in females. Earlier pubertal timing was associated with rsFC increases and decreases across sensory-motor and association networks in females, whereas in males, associations were more limited and localized to sensorimotor and cerebellar systems. Longitudinally, earlier pubertal timing in females predicted reductions in rsFC at the 2-year follow-up, with no significant associations in males. rsFC differences did not explain the pubertal timing and later depressive symptoms association.
CONCLUSIONS: Pubertal timing is associated with sex-specific patterns of brain functional connectivity during early adolescence, with greater heterogeneity and broader network involvement in females. These findings suggest that pubertal maturation contributes to early reorganization of functional brain networks, although these changes did not explain subsequent depressive symptoms.