Oscar Sánchez-Carranza, Valérie Bégay, Sampurna Chakrabarti, Mireia Pampols-Perez, Lin Wang, Jonathan Alexis García-Contreras, Annette Hammes, Gary R. Lewin
mice. These results show that PIEZO2 channels are not the only mechanosensitive channels mediating RA currents in sensory neurons. Furthermore, our data suggest that the phenotypes associated with Piezo2 loss of function alleles may sometimes be due to secondary effects of gene deletion, for example, by changing the developmental trajectory of sensory neurons. Emphasis should be put on the diversity of mechanosensitive ion channel function in sensory neurons, which needs to be further elucidated.