Incidence Trends and Disease Burden of Vascular Intestinal Disorders: A Population-Based Study in China and Worldwide from 1990 to 2021.

PURPOSE: Vascular intestinal disorders (VID), characterized by inadequate intestinal perfusion, lead to severe complications like tissue ischemia, infarction, and inflammation. This study evaluates global and Chinese VID trends and burden from 1990 to 2021 using Global Burden of Disease (GBD) 2021 data. METHODS: Age-standardized incidence, prevalence, mortality, and disability-adjusted life years (DALYs) were extracted. Joinpoint regression analyzed temporal trends, computing average annual percentage changes (AAPC) and 95% confidence intervals. Subgroup analyses covered age, sex, and socio-demographic index. RESULTS: Globally, the age-standardized incidence rate (ASIR) declined from 18.81 to 15.98 per 100,000 (AAPC: -0.52%); in China, it fell from 5.92 to 5.03 (AAPC: -0.50%). However, China's absolute cases nearly doubled due to demographic shifts. Significant gender and age disparities emerged: younger males showed higher ASIR and ASMR, while women ≥75 years had elevated morbidity and mortality. CONCLUSION: Despite declining age-standardized rates, the absolute VID burden escalates globally and in China. Disparities disproportionately affect elderly women and younger males. Enhanced diagnostics, equitable access, and targeted prevention are urgent. Stakeholders must prioritize integrative VID prevention strategies within non-communicable disease frameworks to mitigate this growing concern.