Progress in the development of detoxification strategies and the current application of nanoparticle-based detoxification of pretreated lignocellulosic hydrolysate for bioprocessing in a biorefinery scenario

The production of bioethanol from lignocellulosic biomass (LB) is a promising solution to reduce the dependency on fossil fuels consumption and mitigate the associated environmental challenges. However, the presence of inhibitory compounds in pretreated lignocellulosic hydrolysates poses significant challenges to efficient microbial fermentation, limiting industrial potential of bioethanol production. Hence, this review provides a comprehensive analysis on the detoxification of inhibitory compounds in pretreated lignocellulosic hydrolysate. Likewise, the emerging application of nanoparticle in pretreated lignocellulosic hydrolysate detoxification was discussed. By synthesising existing literature and identifying research gaps, this review also provides insights on potential future innovations in lignocellulosic biorefinery strategies to enhance the feasibility and sustainability of large-scale bioethanol production. Furthermore, a bibliometric analysis highlighting key research trends, influential publications, emerging collaborations and future potential in this field were provided. • Inhibitory compounds are derivatives of pretreated lignocellulosic biomasses (LBs). • Absorption and chemo-complexation are 2 main mechanisms in nano-detoxification. • Nanoparticle-based detoxification of pretreated LBs exhibited high efficiency >29 %. • Nanoparticle-based detoxification is still at its infancy with published articles <1000.